Ovatoxin-a

ovatoxin-a, as the two main compounds responsible for the human poisoning. This was achieved by setting up a new analytical method for detecting palytoxin

Learn more about the change. Preparations of palytoxin (PLTX, derived from Japanese Palythoa tuberculosa) and the congeners 42-OH-PLTX (from Hawaiian P. toxica) and ovatoxin-a (isolated from a Japane Putative palytoxin and ovatoxins were detected, being ovatoxin-a the dominant component. The highest concentration per cell almost coincided with maximum Ostreopsis abundances. Novel Aspect: The improved UHPLC-HRMS method evidences the presence of putative palytoxin and ovatoxins in the Ostreopsis bloom in a NW Mediterranean beach. Create a SciFeed alert for new publications. With following keywords.

09.12.2020 Ovatoxin-a

Herein we report on the NMR‐based elucidation Fragmentation pattern of palytoxin was used as template to gain detailed structural information on ovatoxin-a, the main toxin produced by Ostreopsis ovata, (observe correct font) a benthic dinoflagellate that currently represents the major harmful algal bloom threat in the Mediterranean area. Sep 21, 2013 · Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and environmental suffering. Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three most cases ovatoxin-a was the only toxin detected (83 % of samples), and the remaining 17 % of samples contained it in association with ovatoxin-d/e. Alerted by the repeated occurrence of palytoxin-producing species in the Mediterranean, the European Food Safety Authority (EFSA), in its statement on the areas. At least 8 different PlTX analogues are known: PlTX, ostreocin-D, ovatoxin-A, homopalytoxin, bishomopalytoxin, neopalytoxin, deopalytoxin and 42-hydroxypalytoxin, but only for PlTX and ostreocin-D the chemical structure has been characterised. The occurrence data reported by European The aerosol LD50 values (0.063, 0.045, 0.041, and 0.031 μg/kg for the 50:50 mix, 42-OH PLTX, PLTX, and ovatoxin-a, respectively) confirmed the exquisite potency of PLTX suggested by the literature.

Sep 21, 2013 · Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and environmental suffering. Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three

Structure elucidation of ostreocin-A and ostreocin-E1, novel palytoxin analogs produced by the dinoflagellate Ostreopsis siamensis, using LC/Q-TOF MS. Bioscience, Biotechnology, and Biochemistry: Vol. 83, No. 3, pp. 381-390. We've detected an unusually high number of searches coming from your location. Are you a real person, or a robot?

Apr 04, 2011 · Ciminiello P, Dell'Aversano C, Fatturosso E, Forino M, Tartaglione L, et al. (2008) Putative palytoxin and its analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak. J Am Soc Mass Spectrom 19: 111–120.

Ostreopsis spp. occurrence is presently increasing in the northern to north western UofT Libraries is getting a new library services platform in January 2021. Learn more about the change. Preparations of palytoxin (PLTX, derived from Japanese Palythoa tuberculosa) and the congeners 42-OH-PLTX (from Hawaiian P. toxica) and ovatoxin-a (isolated from a Japane Putative palytoxin and ovatoxins were detected, being ovatoxin-a the dominant component. The highest concentration per cell almost coincided with maximum Ostreopsis abundances. Novel Aspect: The improved UHPLC-HRMS method evidences the presence of putative palytoxin and ovatoxins in the Ostreopsis bloom in a NW Mediterranean beach. Create a SciFeed alert for new publications.

This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf. ovata in the Mediterranean Sea. 3/4/2015 Sigma-Aldrich offers abstracts and full-text articles by [Charline Brissard, Fabienne Hervé, Manoella Sibat, Véronique Séchet, Philipp Hess, Zouher Amzil, Christine Herrenknecht]. On the basis of molecular formula, fragmentation pattern, and chromatographic behavior, the structure of ovatoxin-a appeared to be strictly related to that of palytoxin. We report also on the analysis of cultured O. ovata, which was necessary to unequivocally demonstrate that putative palytoxin and ovatoxin-a contained in field samples were actually produced by O. ovata itself.

17/2/2012 Ovatoxin-a and palytoxin accumulation in seafood in relation to Ostreopsis cf. ovata blooms on the French Mediterranean coast Mar Drugs. 2012 Feb;10(2):477-96. doi: 10.3390/md10020477. Epub 2012 Feb 17. Authors Zouher 1/1/2008 Abstract.

ovata. Laura Pezzolesi, Università di Bologna, Scienze Biologiche, Geologiche e Ambientali Department, Post-Doc. Studies Harmful algal blooms, Benthic Harmful Algal Bloom, and Phytoplankton ecology and distribution. Jun 25, 2020 · Pelin M, Forino M, Brovedani V, Tartaglione L, Dell'Aversano C, Pistocchi R, Poli M, Sosa S, Florio C, Ciminiello P, Tubaro A. Ovatoxin-a, a palytoxin analogue isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic activity and ELISA detection.

ovata in the Mediterranean Sea. This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf. ovata in the Mediterranean Sea. Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve Jun 15, 2019 · The U.S. Army Medical Research Acquisition Activity (USAMRAA) is conducting market research to obtain information regarding services provide Isolation and purification of ovatoxin-a from O. ovata cell pellets to the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). Though palytoxin is 100 times as potent as ovatoxin-a, the isomer can still reach harmful levels in seawater during an algal bloom, Tubaro says. Dec 01, 2012 · An Italian Ostreopsis strain (KAC 85) was also analyzed by LC–MS as a reference material of Ostreopsis and the presence of ovatoxin-a, -b, -c, -d, and -e was re-confirmed.

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Putative palytoxin and ovatoxins were detected, being ovatoxin-a the dominant component. The highest concentration per cell almost coincided with maximum Ostreopsis abundances. Novel Aspect: The improved UHPLC-HRMS method evidences the presence of putative palytoxin and ovatoxins in the Ostreopsis bloom in a NW Mediterranean beach.

Geoditin A, an isomalabaricane triterpene isolated from marine sponge Geodia japonica, has been demonstrated to induce apoptosis in leukemia HL60 cells and human colon HT29 cancer cells through an oxidative stress, a process also interfering with normal melanogenesis in pigment cells. Treatment of murine melanoma B16 cells with geoditin A decreased expression of melanogenic proteins and cell 1009813-91-5 - RZASWFCAHPACCD-FAXBYDSISA-N - Ovatoxin A - Similar structures search, synonyms, formulas, resource links, and other chemical information. Dinoflagellates of the genus Ostreopsis are known to cause (often fatal) food poisoning in tropical coastal areas following the accumulation of palytoxin (PLTX) and/or its analogues (PLTX group) in crabs, sea urchins or fish. Abstract Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf. ovata in the Mediterranean Sea. Ovatoxin A has two oxygen atoms less than PlTX but it is not known from which part of the molecule the oxygen atoms are missing (Ciminiello et al.